The ASINEX’s proprietary building block collection encompasses the legacy of our synthetic know-how and 20+ years of medicinal chemistry expertise with an ultimate goal of delivering novel, valuable chemical monomers for increasingly challenging drug discovery programs.
In addition to commonly popular functionalities such as amines, acids, aldehydes, sulfonyl halides and boronic acids, ASINEX building blocks represent the diversity of other valuable functional groups including alkenes, epoxides, amino alcohols and polyfunctional entities. The later are especially useful for template-based generation of compound libraries where a polyfunctional building block can serve as a core scaffolding structure.
ASINEX Building Blocks have been validated for both chemical stability and reactivity. Many of these building blocks have been utilized for the synthesis of ASINEX natural product-like and macrocyclic libraries as well as for advancing a number of hit-to-lead optimization projects.
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