Publications

Article: General Ser/Thr Kinases Pharmacophore Approach For Selective Kinase Inhibitors Search As Exemplified By Design Of Potent And Selective Aurora A Inhibitors.
Vasilevich NI, Aksenova EA, Kazyulkin DN, Afanasyev II.
Chem Biol Drug Des. 2016 Jan 30
DOI: 10.1111/cbdd.12733

Poster: Compound-to-Target™ platform – small molecule discovery engine for difficult targets.
Mark Parisi, Roman Kombarov, Ramon Jimenez-Moreno, Dmitry Genis
November, 16-17, 2015, 4th Oncology Partnering & Deal-Making Conference , San Francisco, CA, USA
4OP&DMC2015.pdf

Poster: Identification and preliminary structure–activity relationships of novel pyrrolidinyl pyrimidine inhibitors of the Bcl-2 family of antiapoptotic proteins.
S. Breining, A. Shirokov, R. Jimenez-Moreno, O. Roberts, A. Rzepiela, and V. Kochubey.
August, 19, 2015, American Chemical Society 250th National Meeting, Boston, MA, USA
ACS2015.pdf

Article: A Re-examination of the MDM2/p53 Interaction Leads to Revised Design Criteria for Novel Inhibitors.
Vasilevich NI1, Afanasyev II, Kovalskiy DA, Genis DV, Kochubey VS.
Chem Biol Drug Des. 2014 May 2
DOI: 10.1111/cbdd.12351.
 
Article: Dual mode of action of Phenyl-Pyrazole-Phenyl (6-5-6 system) based PPI inhibitors: alpha-helix backbone versus alpha-helix binding epitope.
Natalya Ivanovna Vasilevich, Ilya Afanasyev, Eugene Rastorguev, Dmitry Genis and Valery Kochubey
Med. Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3MD00211J

Article: Determination of flomoxef in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.
Oxana Yu Kravtsova, Sergey A Paramonov, Natalya I Vasilevich, Denis N Kazyulkin, Ekaterina Vlasova, Michael Engsig
Biomedical Chromatography, 2013, Volume 27, Issue 12, pp 1609–1614, 
DOI: 10.1002/bmc.2968

Article: Oxygen-containing fragments in natural products.
Zoya Titarenko, Natalya Vasilevich, Vladimir Zernov, Michael Kirpichenok, Dmitry Genis
J. Comput. Aided Mol. Des., 2013, Feb;27(2), pp 125-160. 
DOI: 10.1007/s10822-012-9629-z

Article: Lessons from natural products chemistry can offer novel approaches for synthetic chemistry in drug discovery.
Natalya I Vasilevich, Roman V Kombarov, Dmitry V Genis, Michael A Kirpichenok
J. Med. Chem., 2012, 55 (16), pp 7003–7009 
DOI: 10.1021/jm300344v

Article: Lessons from natural products chemistry can offer novel approaches for synthetic chemistry in drug discovery.
Natalya I Vasilevich, Roman V Kombarov, Dmitry V Genis, Michael A Kirpichenok
J. Med. Chem., 2012, 55 (16), pp 7003–7009 
DOI: 10.1021/jm300344v

Article: Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1​.
F. Curreli, S. Choudhury, I. Pyatkin, V. Zagorodnikov, A. Bulay, A. Altieri, Y.D. Kwon, P.D. Kwong, A. K. Debnath
J. Med. Chem., 2012, 55 (10), pp 4764–4775
DOI: 10.1021/jm3002247

Article: A minimalist fragment approach for the design of natural-product-like synthetic scaffolds.
Dmitry Genis, Mikhail Kirpichenok, Roman Kombarov
Drug Discovery Today, 2012, Volume 17, 21–22, pp 1170–1174. 
DOI: 10.1016/j.drudis.2012.05.013.

Article: BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery.
Kombarov Roman, Altieri Andrea, Genis Dmitry, Kirpichenok Mikhail, Kochubey Valery, Rakitina Natalia, Titarenko Zoya.
Molecular Diversity, 2010 14(1, pp 193-200. 
DOI: 10.1007/s11030-009-9157-5.