Soft Electrophiles

Product Name Product Description Specification
SL#019 Soft Electrophiles-1 Covalent Inhibitors
Release: 05/21/2016

In screening library creation, reactive molecules have been disregarded due to selectivity and safety concerns. However, many successful drugs act as covalent inhibitors based on a specific reactive group or moiety [1].

In library: Soft Electrophiles
SL#020 Soft Electrophiles-2 Covalent Inhibitors
Release: 05/21/2016

In screening library creation, reactive molecules have been disregarded due to selectivity and safety concerns. However, many successful drugs act as covalent inhibitors based on a specific reactive group or moiety [1].

In library: Soft Electrophiles
SL#022 Soft Electrophiles-3. Covalent Inhibitors
Release: 06/05/2016

In screening library creation, reactive molecules have been disregarded due to selectivity and safety concerns. However, many successful drugs act as covalent inhibitors due to the presence of a specific reactive group or moiety [1].

In library: Soft Electrophiles
SL#027 Soft Electrophiles-4. Covalent Inhibitors
Release: 06/25/2016

Historically, in screening libraries, reactive molecules have been disregarded due to selectivity and safety concerns. However, many successful drugs act as covalent inhibitors based on a specific reactive group or moiety [1].

In library: Soft Electrophiles
SL#037 Soft Electrophiles CN
Release: 08/19/2016

Covalent inhibitors often possess an electrophilic “warhead” which interacts with a nucleophilic residue at the binding site under certain physiological conditions; examples of such electrophilic groups include acrylamides, epoxides, nitriles, and electron-deficient ketones.  

In library: Soft Electrophiles