Immunology-Oncology

Product Name Product Description Specification
SL#021 IDO1 Inhibitors
Release: 06/15/2016

Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic enzyme involved in oxidative catabolism of local tryptophan along the kynurenine pathway. Elevated IDO1 activity inhibits both innate and adaptive immune responses resulting in irresponsiveness to immunological challenges.

In library: IDO inhibitors
SL#026 IRAK4 inhibitors
Release: 08/09/2016

Ser/Thr kinase IRAK4 is a key factor in the transduction of signals from the interleukin receptor (IL-1) and toll-like receptors (TLRs) resulting in cytokine release and promotion of genes controlled by transcription factor NF-kB in response to infection [1].

In library: IRAK4 inhibitors
SL#033: PD1/PD-L1 inhibitors
Release: 09/07/2016

Research has shown that Programmed Death-Ligand 1 (PD-L1) plays a role in suppressing the immune system in some physiological and pathological conditions.

In library: Immunology-Oncology